Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting mitochondiral content from respiratory chain capacity in PGC-1 deficient skeletal muscle. 2013 In press.

Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Oncogenic BRAF Regulates Oxidative Metabolism via PGC1a and MITF. Cancer Cell 2013 Mar 18;23(3):302-15.

Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrell C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui, Han J, Fisher DE, Arany Z. PGC-1 Coactivators Regualte MITF and the Tanning Response. Mol Cell Nov 2013 Jan 10;49(1):145-57.

Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1a Regulates Normal and Pathological Angiogenesis in the Retina. Am J Pathology 2013 Jan;182(1):255-65.

Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z. PGC-1a is Despensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle. PLoS One 2012; 7(7):e41817.

Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker M, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, delMonte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac Angiogenic Imbalance Leads to Peri-partum Cardiomyopathy. Nature 2012 May 17;485(7398):333-8.

Finley L, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. PNAS 2012 Feb 21; 109 (8): 2931-6.

Rowe GC, Jang C, Patten IS, Arany Z. PGC-1beta regulates angiogenesis in skeletal muscle. Am J Physiol Endocrinol Metab. 2011; Jul;301(1):E155-63.

Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram S, Arany Z. The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc. Natl. Acad. Sci. USA. 2009; 106: 21401-6.

Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, and Spiegelman BM. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism. 2005; 1:259-271.

Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, and Spiegelman BM. Transverse aortic constriction leads to accelerated heart failure in mice lacking PGC-1α. Proc. Natl. Acad. Sci. USA. 2006; 103:10086-89.

Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, and Spiegelman BM. The Transcriptional Coactivator PGC-1beta Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle. Cell Metabolism. 2007; 5: 35-46.

Arany Z, Foo SY, Ma Y, Ruas J, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala S, Baek KH, Rosenzweig A, and Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α. Nature. 2008; 451: 1008-13.

Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, and Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation. Proc. Natl. Acad. Sci. USA. 2008; 105: 4721-6.

Selected Recent Reviews

Patten IS and Arany Z. PGC-1 coactivators in the cardiovascular system. Trends Endocriol Metab 2012 Feb;23(2):90-7.

Rowe GC, Jiang A and Arany Z. PGC-1 coactivators in cardiac development and disease. Circ Res. 2010 Oct 1;107(7):825-38

Shoag J and Arany Z. Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler Thromb Vasc Biol 2010 Apr;30(4): 662-6.

Wagner BK and Arany Z. High-throughput real-time PCR for detection of gene-expression levels. Methods Mol Biol. 2009; 486: 167-75.

Arany Z. PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev. 2008; 18: 426-34.

Selected Articles 1995-2004

Arany Z, Sellers WR, Livingston DM and Eckner R. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell. 1994; 77:799-800.

Krek W, Ewen ME, Shirodkar S, Arany Z, Kaelin WG, and Livingston DM. Negative regulation of the growth promoting transcription factor E2F-1 by a stably bound cyclin A-dependent Protein Kinase. Cell. 1994; 78:161-172.

Arany Z, Newsome D, Oldread L, Livingston DM and Eckner R. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature. 1995; 374:81-84.

Arany Z, Huang LE, Eckner RE, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, and Livingston DM. An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. USA. 1996; 93:12969-73.

Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, and Livingston DM. Cooperation of STAT2 and p300/CBP in signaling induced by Interferon-. Nature. 1996; 383:344-7.

Huang LE, Arany Z, Livingston, DM and Bunn HF. Activation of Hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its subunit. J. Biol. Chem. 1996; 271:32253-9.

Eckner R, Ludlow JW, Lill NL, Oldread E, Arany Z, Modjtahedi N, DeCaprio JA, Livingston DM, and Morgan JA. Association of p300 and CBP with Simian Virus 40 Large T Antigen. Mol. Cell. Biol. 1996; 16:3454-64.

Bhattacharya S, Michels CL, Leung MK, Arany Z, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes & Development. 1999; 13:64-75.