<%@LANGUAGE="JAVASCRIPT" CODEPAGE="936"%> Arany Lab
 
           
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Selected Recent Articles

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. Genes Dev. 2016 Dec 2. [Epub ahead of print]

Heme oxygenase and carbon monoxide protect from muscle dystrophy. Chan MC, Ziegler O, Liu L, Rowe GC, Das S, Otterbein LE, Arany Z. Skelet Muscle. 2016 Nov 28;6(1):41.

Cardiogenic shock in pregnancy: Analysis from the National Inpatient Sample. Banayan J, Rana S, Mueller A, Tung A, Ramadan H, Arany Z, Nizamuddin J, Novack V, Scavone B, Brown SM, Shahul S. Hypertens Pregnancy. 2016 Nov 11:1-7. [Epub ahead of print]

Circulating Antiangiogenic Factors and Myocardial Dysfunction in Hypertensive Disorders of Pregnancy. Shahul S, Medvedofsky D, Wenger JB, Nizamuddin J, Brown SM, Bajracharya S, Salahuddin S, Thadhani R, Mueller A, Tung A, Lang RM, Arany Z, Talmor D, Karumanchi SA, Rana S. Hypertension. 2016 Jun;67(6):1273-80.

Relaxin-2 and Soluble Flt1 Levels in Peripartum Cardiomyopathy: Results of the Multicenter IPAC Study. Damp J, Givertz MM, Semigran M, Alharethi R, Ewald G, Felker GM, Bozkurt B, Boehmer J, Haythe J, Skopicki H, Hanley-Yanez K, Pisarcik J, Halder I, Gorcsan J 3rd, Rana S, Arany Z, Fett JD, McNamara DM; IPAC Investigators.. JACC Heart Fail. 2016 May;4(5):380-8.

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity. Iacovelli J, Rowe GC, Khadka A, Diaz-Aguilar D, Spencer C, Arany Z, Saint-Geniez M. Invest Ophthalmol Vis Sci. 2016 Mar;57(3):1038-51.

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. Nat Med. 2016 Apr;22(4):421-6.

Exercise-induced mitochondrial p53 repairs mtDNA mutations in mutator mice. Safdar A, Khrapko K, Flynn JM, Saleem A, De Lisio M, Johnston AP, Kratysberg Y, Samjoo IA, Kitaoka Y, Ogborn DI, Little JP, Raha S, Parise G, Akhtar M, Hettinga BP, Rowe GC, Arany Z, Prolla TA, Tarnopolsky MA.Skelet Muscle. 2016 Jan 31;6:7.

Salma N, Song JS, Arany Z, Fisher DE. Transcription Factor TFE3 Directly Regulates PGC-1apha in Muscle. J Cell Physiol. 2015 Oct;230(10):2330-6.

Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z. Shared Genetic Etiology of Peripartum and Dilated Cardiomyopathies. N Engl J Med. 2016 Jan 21;374(3):233-41.

Rowe GC, Raghuram S, Jang C, Nagy JA, Patten IS, Goyal A, Chan MC, Liu LX, Jiang A, Spokes K, Beeler D, Dvorak H, Aird WC, Arany Z. PGC-1alpha Induces SPP1 to Activate Macrophages and Orchestrate Functional Angiogenesis in Skeletal Muscle. Circulation Research. 2014 115:504-17.

Arany ZP, Walker CM, Wang L. Case records of the Massachusetts General Hospital. Case 22-2014. A 40-year-old woman with postpartum dyspnea and hypoxemia. N Engl J Med. 2014 Jul 17;371(3):261-9.

Thom R, Rowe GC, Jang C, Safdar A, Arany Z. Hypoxic Induction of Vascular Endothelial Growth Factor (VEGF) and Angiogenesis in Muscle by Truncated Peroxisome Proliferator-Activated Receptor Gamma Coactivator (PGC)-1alpha. JBC 2014 March 28, 289 (13) 8810-8817.

Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Endothelial PGC-1α Mediates Vascular Dysfunction in Diabetes. Cell Met 2014 Feb 4;19(2):246-58.

Chan MC, Rowe GC, Raghuram S, Patten IS, Farrell C, Arany Z. Post-natal induction of PGC-1alpha protects against severe muscle dystrophy independently of utrophin. Skeletal Muscle. 2014 Jan 22;4(1):2.

Bello N, Hurtado Rendon IS, Arany Z. The relationship between Preeclampsia and Peripartum Cardiomyopathy: a Systematic Review and Meta-Analysis. J Am Coll Cardiol 2013 Aug 23 S0735-1097(13)04005-9.

Rowe GC, Patten IS, Zsengeller ZK, El-Khoury R, Okutsu M, Bampoh S, Koulisis N, Farrell C, Hirshman MF, Yan Z, Goodyear LJ, Rustin P, Arany Z. Disconnecting mitochondiral content from respiratory chain capacity in PGC-1 deficient skeletal muscle. Cell Rep 2013 May 30;3(5):1449-56.

Haq R, Shoag J, Andreu-Perez P, Yokoyama S, Edelman H, Rowe GC, Frederick DT, Hurley AD, Nellore A, Kung AL, Wargo JA, Song JS, Fisher DE, Arany Z, Widlund HR. Oncogenic BRAF Regulates Oxidative Metabolism via PGC1a and MITF. Cancer Cell 2013 Mar 18;23(3):302-15.

Shoag J, Haq R, Zhang M, Liu L, Rowe GC, Jiang A, Koulisis N, Farrell C, Amos CI, Wei Q, Lee JE, Zhang J, Kupper TS, Qureshi AA, Cui, Han J, Fisher DE, Arany Z. PGC-1 Coactivators Regualte MITF and the Tanning Response. Mol Cell Nov 2013 Jan 10;49(1):145-57.

Saint-Geniez M, Jiang A, Abend S, Liu L, Sweigard H, Connor KM, Arany Z. PGC-1a Regulates Normal and Pathological Angiogenesis in the Retina. Am J Pathology 2013 Jan;182(1):255-65.

Rowe GC, El-Khoury R, Patten IS, Rustin P, Arany Z. PGC-1a is Despensable for Exercise-Induced Mitochondrial Biogenesis in Skeletal Muscle. PLoS One 2012; 7(7):e41817.

Patten IS, Rana S, Shahul S, Rowe GC, Jang C, Liu L, Hacker M, Rhee JS, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin EV, Burke SD, Tudorache I, Bauersachs J, delMonte F, Hilfiker-Kleiner D, Karumanchi SA, Arany Z. Cardiac Angiogenic Imbalance Leads to Peri-partum Cardiomyopathy. Nature 2012 May 17;485(7398):333-8.

Finley L, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle PGC-1α mediates mitochondrial, but not metabolic, changes during calorie restriction. PNAS 2012 Feb 21; 109 (8): 2931-6.

Rowe GC, Jang C, Patten IS, Arany Z. PGC-1beta regulates angiogenesis in skeletal muscle. Am J Physiol Endocrinol Metab. 2011; Jul;301(1):E155-63.

Chinsomboon J, Ruas J, Gupta RK, Thom R, Shoag J, Rowe GC, Sawada N, Raghuram S, Arany Z. The transcriptional coactivator PGC-1alpha mediates exercise-induced angiogenesis in skeletal muscle. Proc. Natl. Acad. Sci. USA. 2009; 106: 21401-6.

Arany Z, He H, Lin J, Hoyer K, Handschin C, Toka O, Ahmad F, Matsui T, Chin S, Wu PH, Rybkin II, Shelton JM, Manieri M, Cinti S, Schoen FJ, Bassel-Duby R, Rosenzweig A, Ingwall JS, and Spiegelman BM. Transcriptional coactivator PGC-1α controls the energy state and contractile function of cardiac muscle. Cell Metabolism. 2005; 1:259-271.

Arany Z, Novikov M, Chin S, Ma Y, Rosenzweig A, and Spiegelman BM. Transverse aortic constriction leads to accelerated heart failure in mice lacking PGC-1α. Proc. Natl. Acad. Sci. USA. 2006; 103:10086-89.

Arany Z, Lebrasseur N, Morris C, Smith E, Yang W, Ma Y, Chin S, and Spiegelman BM. The Transcriptional Coactivator PGC-1beta Drives the Formation of Oxidative Type IIX Fibers in Skeletal Muscle. Cell Metabolism. 2007; 5: 35-46.

Arany Z, Foo SY, Ma Y, Ruas J, Bommi-Reddy A, Girnun G, Cooper M, Laznik D, Chinsomboon J, Rangwala S, Baek KH, Rosenzweig A, and Spiegelman BM. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α. Nature. 2008; 451: 1008-13.

Arany Z, Wagner BK, Ma Y, Chinsomboon J, Laznik D, and Spiegelman BM. Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1α and oxidative phosphorylation. Proc. Natl. Acad. Sci. USA. 2008; 105: 4721-6.

Selected Recent Reviews

Response by Arany and Elkayam to Letter Regarding Article, "Peripartum Cardiomyopathy". Arany Z, Elkayam U. Circulation. 2016 Aug 16;134(7):e83-4.

Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. Ware JS, Seidman JG, Arany Z. N Engl J Med. 2016 Jun 30;374(26):2601-2.

Editorial Commentary: Guidance through the "Toolshed" for endovascular revascularization of the lower extremity. Giri J, Arany Z. Trends Cardiovasc Med. 2016 Aug;26(6):513-4.

Peripartum Cardiomyopathy. Arany Z, Elkayam U. Circulation. 2016 Apr 5;133(14):1397-409.

Echoes of Preeclampsia: Can Echocardiography Help Predict Recurrence? Khankin EV, Arany Z. Hypertension. 2016 Apr;67(4):690-2.

Bello N, Arany Z. Molecular Mechanisms of Peripartum Cardiomyopathy: a Vascular/Hormonal Hypothesis. Trends in Cardiovasc. Med. Trends Cardiovasc Med. 2015 Jan 15.

Arany Z, Walker CM, Wang L. A 40-Year Old Woman with Dyspnea and Hypoxemia Post-Partum. New England Journal of Medicine. 2014 Jul 17;371(3):261-9.

Chan MC and Arany Z. The many roles of PGC-1α in muscle - recent developments. Metabolism. 2014 Apr;63(4):441-451.

Hilfiker-Kleiner D and Arany Z. Focus on Pregnancy-mediated Heart & Vascular Disease. Cardiovasc Res. 2014 Mar 15;101(4):543-4.

Liu LX and Arany Z. Maternal Cardiac Metabolism in Pregnancy. Cardiovasc Res. 2014 Mar 15;101(4):545-53.

Rowe GC, Safdar A, Arany Z. Running forward: new frontiers in endurance exercise biology. Circulation. 2014 Feb 18;129(7):798-810.

Rowe GC and Arany Z. Genetic models of PGC-1 and glucose metabolism and homeostasis. Rev Endocr Metab Disord. 2014 Mar;15(1):21-9.

Jang C and Arany Z. Metabolism: Sweet enticement to move. Nature Aug 22;500(7463):409-11.

Patten IS and Arany Z. PGC-1 coactivators in the cardiovascular system. Trends Endocriol Metab 2012 Feb;23(2):90-7.

Rowe GC, Jiang A and Arany Z. PGC-1 coactivators in cardiac development and disease. Circ Res. 2010 Oct 1;107(7):825-38

Shoag J and Arany Z. Regulation of hypoxia-inducible genes by PGC-1 alpha. Arterioscler Thromb Vasc Biol 2010 Apr;30(4): 662-6.

Wagner BK and Arany Z. High-throughput real-time PCR for detection of gene-expression levels. Methods Mol Biol. 2009; 486: 167-75.

Arany Z. PGC-1 coactivators and skeletal muscle adaptations in health and disease. Curr Opin Genet Dev. 2008; 18: 426-34.

 

Selected Articles 1995-2004

Arany Z, Sellers WR, Livingston DM and Eckner R. E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell. 1994; 77:799-800.

Krek W, Ewen ME, Shirodkar S, Arany Z, Kaelin WG, and Livingston DM. Negative regulation of the growth promoting transcription factor E2F-1 by a stably bound cyclin A-dependent Protein Kinase. Cell. 1994; 78:161-172.

Arany Z, Newsome D, Oldread L, Livingston DM and Eckner R. A family of transcriptional adaptor proteins targeted by the E1A oncoprotein. Nature. 1995; 374:81-84.

Arany Z, Huang LE, Eckner RE, Bhattacharya S, Jiang C, Goldberg MA, Bunn HF, and Livingston DM. An essential role for p300/CBP in the cellular response to hypoxia. Proc. Natl. Acad. Sci. USA. 1996; 93:12969-73.

Bhattacharya S, Eckner R, Grossman S, Oldread E, Arany Z, D'Andrea A, and Livingston DM. Cooperation of STAT2 and p300/CBP in signaling induced by Interferon-. Nature. 1996; 383:344-7.

Huang LE, Arany Z, Livingston, DM and Bunn HF. Activation of Hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its subunit. J. Biol. Chem. 1996; 271:32253-9.

Eckner R, Ludlow JW, Lill NL, Oldread E, Arany Z, Modjtahedi N, DeCaprio JA, Livingston DM, and Morgan JA. Association of p300 and CBP with Simian Virus 40 Large T Antigen. Mol. Cell. Biol. 1996; 16:3454-64.

Bhattacharya S, Michels CL, Leung MK, Arany Z, Kung AL, Livingston DM. Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes & Development. 1999; 13:64-75.

 

 

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Last Update December/2016